Location

The Clelland lab is located in the Weill Institute for Neurosciences building on the UCSF Mission Bay campus. We are located in close proximity to our collaborators at UCSF, the Gladstone Institutes and the Innovative Genomics Institute at UC Berkeley. 

Our Research

The Clelland lab is devoted to developing novel therapies for neurodegenerative diseases. We are currently creating CRISPR gene editing therapies for neurodegenerative diseases. We are focusing first on FTD and ALS caused by single gene mutations, since this class of monogenic neurodegenerative disease is likely to be cured by gene correction.

Current Open Questions in the Lab

What is the best CRISPR editing approach to correct the C9orf72 mutation?

iPSC modeling: How can we better model human disease using cell types (such as neurons and microglia) derived from human patients?

How can we deliver CRISPR to the brain and spinal cord?

Can we correct GRN haploinsufficiency by preferentially upregulating the normal (non-diseased) allele?

Can we build a better human cellular model of Alzheimer's disease?

Lab Openings

We are currently hiring for the following positions:

Postdoctoral fellow: Please send your CV and cover letter to Claire at email