Publications

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Proc Natl Acad Sci USA 121, e2307814121. https://doi.org/10.1073/pnas.2307814121.

Sachdev, A., Gill, K., Sckaff, M., Birk, A.M., Aladesuyi Arogundade, O., Brown, K.A., Chouhan, R.S., Issagholian-Lewin, P.O., Patel, E., Watry, H.L., Bernardi, M.T., Keough, K.C., Tsai, Y.-C., Smith, A.S.T., Conklin, B.R., Clelland, C.D., 2024. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Novel avenues of tau research.

Alzheimers Dement 20, 2240–2261. https://doi.org/10.1002/alz.13533.

Sexton, C.E., Bitan, G., Bowles, K.R., Brys, M., Buée, L., Maina, M.B., Clelland, C.D., Cohen, A.D., Crary, J.F., Dage, J.L., Diaz, K., Frost, B., Gan, L., Goate, A.M., Golbe, L.I., Hansson, O., Karch, C.M., Kolb, H.C., La Joie, R., Lee, S.E., Matallana, D., Miller, B.L., Onyike, C.U., Quiroz, Y.T., Rexach, J.E., Rohrer, J.D., Rommel, A., Sadri-Vakili, G., Schindler, S.E., Schneider, J.A., Sperling, R.A., Teunissen, C.E., Weninger, S.C., Worley, S.L., Zheng, H., Carrillo, M.C., 2024.

Validated assays for the quantification of C9orf72 human pathology.

Sci. Rep. 14, 828. https://doi.org/10.1038/s41598-023-50667-3.

Salomonsson, S.E., Maltos, A.M., Gill, K., Aladesuyi Arogundade, O., Brown, K.A., Sachdev, A., Sckaff, M., Lam, K.J.K., Fisher, I.J., Chouhan, R.S., Van Laar, V.S., Marley, C.B., McLaughlin, I., Bankiewicz, K.S., Tsai, Y.C., Conklin, B.R., Clelland, C.D., 2024. Validated assays for the quantification of C9orf72 human pathology.

Building CRISPR gene therapies for the central nervous system: A review.

JAMA Neurol. 81, 283–290. https://doi.org/10.1001/jamaneurol.2023.4983.

Salomonsson, S.E., Clelland, C.D., 2024. Building CRISPR gene therapies for the central nervous system: A review.

Functional characterization of Alzheimer's disease genetic variants in microglia.

Nat. Genet. 55, 1735–1744. https://doi.org/10.1038/s41588-023-01506-8.

Yang, X., Wen, J., Yang, H., Jones, I.R., Zhu, X., Liu, W., Li, B., Clelland, C.D., Luo, W., Wong, M.Y., Ren, X., Cui, X., Song, M., Liu, H., Chen, C., Eng, N., Ravichandran, M., Sun, Y., Lee, D., Van Buren, E., Jiang, M.-Z., Chan, C.S.Y., Ye, C.J., Perera, R.M., Gan, L., Li, Y., Shen, Y., 2023. Functional characterization of Alzheimer’s disease genetic variants in microglia.

Two therapeutic CRISPR/Cas9 gene editing approaches revert FTD/ALS cellular pathology caused by a C9orf72 repeat expansion mutation in patient derived cells

BioRxiv. https://doi.org/10.1101/2022.05.21.492887.

Sckaff, M., Gill, K., Sachdev, A., Birk, A.M., Aladesuyi Arogundade, O., Watry, H.L., Keough, K.C., Tsai, Y.C., Ziegle, J., Conklin, B.R., Clelland, C.D., 2022. Two therapeutic CRISPR/Cas9 gene editing approaches revert FTD/ALS cellular pathology caused by a C9orf72 repeat expansion mutation in patient derived cells.

POSTERS:

Sachdev A, Kamal G, Sckaff M, Birk A, Arongundade AO, Keough K, Tsai Y-C, Conklin BR, Clelland CD. Two therapeutic CRISPR/Cas9 gene editing approaches cure pathology caused by the FTD/ALS-causing C9orf72 repeat expansion mutation in patient iPSCs. Cold Springs Harbor meeting; Genome Engineering: CRISPR Frontiers, 2022, Huntington, NY. 

  

Aradhana Sachdev, BA, Kamaljot Gill, BA, Maria Sckaff, BS, Alisha M. Birk, BS, Olubankole Aladesuyi Arongundade, PhD, Kathleen Keough, PhD, Bruce R. Conklin, MD, Claire Clelland, PhD, MD, MPhil. Reversal Of C9orf72 Mutation-induced Transcriptional Dysregulation And Pathology In Cultured Human Neurons By Allele-specific Excision. 148th Annual meeting of the American Neurological Association, 2023, Philadelphia, PA. 

  

Aradhana Sachdev, BA, Kamaljot Gill, BA, Maria Sckaff, BS, Alisha M. Birk, BS, Olubankole Aladesuyi Arongundade, PhD, Kathleen Keough, PhD, Bruce R. Conklin, MD, Claire Clelland, PhD, MD, MPhil. Reversal Of C9orf72 Mutation-induced Transcriptional Dysregulation And Pathology In Cultured Human Neurons By Allele-specific Excision. ANA-NINDS Career Development Symposium, 2023, Philadelphia, PA. 

  

Aradhana Sachdev, BA, Kamaljot Gill, BA, Maria Sckaff, BS, Alisha M. Birk, BS, Olubankole Aladesuyi Arongundade, PhD, Kathleen Keough, PhD, Bruce R. Conklin, MD, Claire Clelland, PhD, MD, MPhil. Reversal Of C9orf72 Mutation-induced Transcriptional Dysregulation And Pathology In Cultured Human Neurons By Allele-specific Excision. NIH Somatic Cell Genome Engineering Consortium bi-annual conference, 2023, Bethesda, MD. 

  

Candelaria Beletran-Moreno, Olubankole Aladesuyi, Claire D. Clelland. Sustained Release PODS for Growth Factor Delivery in Neurons. CIRM Internship Symposium, 2023, San Francisco, CA. 

  

Brynn Kroke, Isabelle J. Fisher, Sally Salomonsson, Claire D. Clelland. Novel ddPCR Assay to Quantify MAPT RNA Isoform and Mutant vs Wild Type Expression in FTD Patient-Derived Neurons. STRP Symposum, 2023, San Francisco, CA. 

  

Isabelle J. Fisher, Isabella Sanchez, Brynn Kroke, Ebtesam Hassan, Claire D. Clelland. Novel ddPCR Assay to Quantify MAPT RNA Isoform and Mutant vs Wild Type Expression in FTD Patient-Derived Neurons. Dementia Day, 2023, San Francisco, CA. 

  

Aradhana Sachdev, BA, Kamaljot Gill, BA, Maria Sckaff, BS, Alisha M. Birk, BS, Olubankole Aladesuyi Arongundade, PhD, Katherine A Brown, BA, Runvir S Chouhan BS, Patrick Issagholian Lewin CS, Esha Patel, Kathleen Keough, PhD, Bruce R. Conklin, MD, Alec ST Smith, PhD, Claire Clelland, PhD, MD, MPhil. Reversal Of C9orf72 Mutation-induced Transcriptional Dysregulation And Pathology In Cultured Human Neurons By Allele-specific Excision. AAIC Neuro Next, 2024, San Francisco, CA. 

  

Katie Jing Kay Lam, MS, Olubankole Aladesuyi Arongundade, PhD, Claire D Clelland, PhD, MD, MPhil. Identification of Candidate Therapeutic Targets for Excising the C9orf72 Hexanucleotide Repeat Expansion using Arrayed CRISPR Screens in Patient iPSCs. 24th Annual Packard Center ALS Research Symposium, 2024, Baltimore, MD. 

  

Katherine A. Brown, Saeed Fathi, Tanya Jain, Olubankole Aladesuyi Arongundade, Claire D. Clelland. Effects of C9orf72 repeat length on FTD/ALS pathological hallmarks in engineered patient iPSCs. 24th Annual Packard Center ALS Research Symposium, 2024, Baltimore, MD.